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August 2003, 3:4 > Drug-induced
autoimmunity. |
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ARTICLE LINKS:
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Drug-induced autoimmunity.
Drug Allergy
Current Opinion in Allergy & Clinical Immunology. 3(4):249-253,
August 2003.
Pichler, Werner J.
Abstract:
Purpose of review: Presentation of different mechanism of drug-induced
autoimmunity and highlighting of new developments.
Recent findings: Drugs can induce autoimmune diseases by their
pharmacological properties. Injection of certain drugs into the thymus can
alter positive selection in the thymus and elicit autoimmune reactions. Peripheral
tolerance can be broken by increasing the expression of LFA-1 adhesion molecule
on T cells. This can be related to the inhibition of intracellular kinases. Alternatively, a drug specific immune response
might elicit autoimmunity by cross-reactivity: the drug reactive T cells might
be cross-reactive with certain peptide antigens and possibly autoantigens.
Summary: Drug-specific immune responses are well described. They have a
great tendency to be cross-reactive with peptide antigens. This 'immunological'
cause of autoimmunity elicited by drugs may occur more frequently than thought.
It connects the field of drug hypersensitivity with drug-induced autoimmunity.
(C) 2003 Lippincott Williams & Wilkins,
Inc.
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